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In vivo Evaluation of the ability to reduce cholesterol by three isolated indigenous lactic acid bacteria with probiotic potential

In this study the effect of consumption of the milk containing three probiotic strains of  A, B and C isolated from traditional dairy products of Lighvan on serum lipid profile of the rats was evaluated. For the experiment white rat, strain Wistar Albino with weight mean of 250 g, age of 8 week and the male sex was selected. The rats were feeded by oily food for 60 days. Each rat was daily feeded by definite dose of bacteria combined by daily food. The experiment was carried out in 4 treatments, 3 repetitions in Complete Random Design. Dunkan test was used for mean comparisons. The method for cholestrol, plasma triglyceride as well as HDL- C, LDL- C and VLDL- C of blood serum was enzymatic- clolour metering. According to obtained results of blood plasma analysis, the serum cholestrol reduction was observed by daily consumption of three probiotics for 8 weeks. The cholestrol amount of group A, B and C was respectively 21.5, 23.5 and 25.6 % less than control group. Further this significant reduction was observed in the results of plasma triglyceride (control: 41, A: 35, B: 34 and C: 34 mg/dl). HDL- C of rat serum in control, A, B and C was respectively 94, 80, 85 and 84 mg/dl. The data related to LDL- C of the sera showed the cholestrol reduction in probiotic consuming group compared to control which was equal to 33, 28, 27 and 28 mg/dl.  The reduction in VLDL-C was as control: 8, A: 7, B: 6.8 and C: 6.7 mg/dl. The result demonstrates that the native probiotic strains are able to reduce different levels of cholestrol.


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